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LodeRx
LODERX BLOG

Guides, research, and straight talk.

What clinicians actually know about peptide therapy, GLP-1s, and TRT — written for patients, reviewed by physicians.

Weekly vs. Microdosing Semaglutide: How Clinicians Approach Compounded Dosing Schedules
glp-1

Weekly vs. Microdosing Semaglutide: How Clinicians Approach Compounded Dosing Schedules

Clinicians compare once-weekly semaglutide titration with microdosing frameworks: evidence, risks, and how compounded doses are prescribed and dispensed.

August 10, 2026
Injection Site Rotation for TRT and GLP-1: What Clinicians Recommend
trt

Injection Site Rotation for TRT and GLP-1: What Clinicians Recommend

How clinicians recommend rotating TRT and GLP-1 injection sites to reduce scar tissue and support consistent absorption, with cited clinical sources.

August 10, 2026
Longevity Biomarkers Beyond Bloodwork: HRV, VO2 Max, and Grip Strength Explained
longevity

Longevity Biomarkers Beyond Bloodwork: HRV, VO2 Max, and Grip Strength Explained

HRV, VO2 max, and grip strength are functional longevity biomarkers labs can't capture. Learn what they measure, why they matter, and how to track them.

August 9, 2026
Subcutaneous vs Intramuscular TRT Injection: How Clinicians Frame the Choice
trt

Subcutaneous vs Intramuscular TRT Injection: How Clinicians Frame the Choice

Subcutaneous vs intramuscular testosterone injection: what the research shows on absorption, comfort, and dosing frequency, and how clinicians decide.

August 8, 2026
GLP-1 Discontinuation and Weight Regain: What the Research Shows
glp-1

GLP-1 Discontinuation and Weight Regain: What the Research Shows

Research shows most people regain a majority of lost weight after stopping GLP-1 therapy. Here's what the studies say and what to discuss with a clinician.

August 7, 2026
Peptide Storage and Reconstitution Basics: What to Ask Your Pharmacy
peptides

Peptide Storage and Reconstitution Basics: What to Ask Your Pharmacy

How lyophilized peptides should be stored, what happens during reconstitution, and the questions worth asking the 503A pharmacy that compounds your prescription.

August 6, 2026
Reading Your Comprehensive Metabolic Panel: What Men Should Know
bloodwork

Reading Your Comprehensive Metabolic Panel: What Men Should Know

A comprehensive metabolic panel covers 14 markers for kidney, liver, blood sugar, and electrolyte health. Here's how men can read the numbers with context.

August 5, 2026
Compounded GLP-1s After the Shortage: What Current 503A Rules Mean for Access
glp-1

Compounded GLP-1s After the Shortage: What Current 503A Rules Mean for Access

The national GLP-1 shortage has ended. Here's what FDA's 503A rules actually allow now, who still qualifies for compounded access, and how to check your options.

August 4, 2026
TRT and Cardiovascular Safety: What the Current Evidence Actually Shows
trt

TRT and Cardiovascular Safety: What the Current Evidence Actually Shows

TRAVERSE and other trials clarify TRT's cardiovascular risk profile. Here's what the data says, what remains uncertain, and how clinicians monitor heart risk on therapy.

August 3, 2026
TRT Bloodwork Panels: What Men Should Ask Their Clinician About
TRT bloodwork panel questions to ask your clinician

TRT Bloodwork Panels: What Men Should Ask Their Clinician About

A guide to TRT bloodwork panels: baseline and monitoring labs, what hematocrit and estradiol results mean, and questions to bring to your clinician.

August 2, 2026
Growth Hormone Secretagogues Explained: How CJC-1295 and Ipamorelin Work
peptides

Growth Hormone Secretagogues Explained: How CJC-1295 and Ipamorelin Work

What are growth hormone secretagogues? A clear look at how CJC-1295 and ipamorelin work, what the research shows, and how compounded peptide access works.

August 2, 2026
Longevity Supplements: Which Ones Have Real Evidence and Which Don't
longevity

Longevity Supplements: Which Ones Have Real Evidence and Which Don't

A clinical look at which longevity supplements have human trial data behind them, and which popular ones remain unproven or carry risk at high doses.

August 2, 2026