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LODERX BLOG

Guides, research, and straight talk.

What clinicians actually know about peptide therapy, GLP-1s, and TRT — written for patients, reviewed by physicians.

Creatine for Longevity: What the Evidence Supports in Men 30 to 55
longevity

Creatine for Longevity: What the Evidence Supports in Men 30 to 55

A look at what peer-reviewed research actually supports on creatine, muscle preservation, and cognitive aging in men 30 to 55, and where it fits with clinician-guided care.

September 26, 2026
Intermittent Fasting for Longevity: What the Research Shows and What It Doesn't
longevity

Intermittent Fasting for Longevity: What the Research Shows and What It Doesn't

A clear look at intermittent fasting research on aging and longevity: what animal and human studies actually support, and where the evidence runs out.

September 26, 2026
Are Compounded Peptides Legal? The FDA's Current Regulatory Posture Explained
peptides

Are Compounded Peptides Legal? The FDA's Current Regulatory Posture Explained

A plain-language breakdown of the FDA's 2023-2026 compounded peptide rules, Category 2 substances, and what the agency's advisory review means for patients.

September 26, 2026
503A vs. 503B Pharmacies: Why the Compounding Pathway Determines Peptide Access
peptides

503A vs. 503B Pharmacies: Why the Compounding Pathway Determines Peptide Access

503A and 503B pharmacies follow different FDA rules, and that difference decides which peptides a clinician can legally prescribe. Here's what it means for patients.

September 26, 2026
Free Testosterone vs Total Testosterone: Which Number Actually Matters?
trt

Free Testosterone vs Total Testosterone: Which Number Actually Matters?

Total and free testosterone measure different things. Here's what each number means, when SHBG changes the picture, and how clinicians read both together.

September 26, 2026
Thyroid Panel Basics: What Men's Health Labs Typically Include
thyroid

Thyroid Panel Basics: What Men's Health Labs Typically Include

What TSH, Free T4, Free T3, and antibody tests actually check, and how thyroid labs fit into a broader men's hormone workup.

September 26, 2026
Resting Heart Rate as a Longevity Marker: What Clinicians Actually Look For
longevity

Resting Heart Rate as a Longevity Marker: What Clinicians Actually Look For

Resting heart rate is a simple, well-studied longevity marker. Here's what the research shows, what counts as normal, and when clinicians flag it.

September 26, 2026
Peptide Half-Life and Injection Frequency: How Clinicians Think About Timing
peptides

Peptide Half-Life and Injection Frequency: How Clinicians Think About Timing

How clinicians use a peptide's half-life, not just its dose, to determine injection frequency, steady-state timing, and why short-acting doesn't always mean daily.

September 26, 2026
PT-141: What the Research Says About Its Current FDA Regulatory Status
peptides

PT-141: What the Research Says About Its Current FDA Regulatory Status

Is PT-141 FDA-approved? Learn how Vyleesi's 2019 approval differs from compounded PT-141, what the research shows, and how prescribing actually works.

September 26, 2026
Growth Hormone Secretagogues and Sleep: What the Research Suggests
peptides

Growth Hormone Secretagogues and Sleep: What the Research Suggests

What peer-reviewed research on growth hormone secretagogues and sleep actually shows, including slow-wave sleep, GH pulses, and where the evidence has gaps.

September 17, 2026
What Factors Into the Monthly Cost of Compounded GLP-1 Medications
glp-1

What Factors Into the Monthly Cost of Compounded GLP-1 Medications

Compounded GLP-1 pricing varies widely. Here's what actually drives the monthly cost, from pharmacy sourcing to clinical monitoring, and how to evaluate a quote.

September 17, 2026
GLP-1 Appetite Changes: What to Expect in the First Few Weeks
glp-1

GLP-1 Appetite Changes: What to Expect in the First Few Weeks

What GLP-1 appetite changes typically feel like week by week, why responses vary, and when reduced hunger warrants a call to your clinician.

September 16, 2026