The one that
started it all.
Compounded semaglutide with B12 — a prescription GLP-1 receptor agonist prepared under Section 503A — in a once-weekly injection a licensed clinician titrates to how you respond.
Prescribed only when clinically appropriate, at a licensed provider's discretion. Available in all 50 states. Not sure it's the right GLP-1 for you? Compare weight-loss programs →
Less willpower. More result.
GLP-1 acts on appetite signaling. Most members notice cravings drop inside the first few weeks, before the scale moves.
Steady, sustainable loss month over month, with the dose titrated so it keeps working without wrecking your week.
Energy and mood lift as the weight comes off and the healthy habits stop feeling like a second job.
How semaglutide actually works.
Plain answers to what your clinician will cover, no forum myths.
What is semaglutide?+
A GLP-1 receptor agonist — it mimics a natural gut hormone that regulates appetite and blood sugar. LodeRx uses compounded semaglutide with B12, prepared by state-licensed US pharmacies under Section 503A of the FD&C Act and prescribed by a clinician when appropriate. Compounded medications are not FDA-approved.
How does it help me lose weight?+
It slows how fast your stomach empties and signals fullness to your brain, so you eat less without fighting constant hunger. Your dose steps up slowly over weeks — that ramp is managed by your clinician, not left to guesswork.
Why is B12 in it?+
The compounded formulation pairs semaglutide with vitamin B12, commonly used in compounding to support the formulation. Your clinician covers exactly what's in your prescription before you start.
Is it right for me?+
GLP-1 therapy is typically for adults with a qualifying BMI or a weight-related condition — your clinician decides from your history. It isn't for everyone: a personal or family history of medullary thyroid carcinoma, MEN 2, pancreatitis, or pregnancy are among the reasons it may not be appropriate.
What about side effects?+
The most common are gastrointestinal — nausea, constipation, reflux — mostly while the dose ramps. For most people they ease with time and titration. Your clinician adjusts the ramp if it's rough; that's what the check-ins are for.
Three steps to a quieter appetite.
Choose your plan and complete a short medical intake — history, weight goals, any conditions. Prefer to talk first? Request a call.
A provider licensed in your state reviews your file and decides if semaglutide is appropriate. If it isn't, you get a straight answer, not a workaround.
Medication arrives cold from a certified US pharmacy with syringes included. Your care team guides the weekly ramp and check-ins.
Asked constantly. Answered honestly.
Why is it more affordable than what my neighbor is paying?+
Compounded medications are prepared by state-licensed US pharmacies under Section 503A of the FD&C Act, based on a patient-specific prescription from a licensed clinician. That prescribing pathway is what makes cash-pay access possible without going through insurance.
Do I have to inject myself?+
Yes — once a week, with a small insulin-gauge needle. Your care team walks you through the first one. If needles are a hard no, look at the oral tablet version instead.
How fast will I see results?+
Appetite changes often show up in the first couple of weeks; visible weight change builds over the following months as the dose titrates. Steady beats dramatic — it's more likely to stay off.
Can I use HSA/FSA, and can I stop?+
Many members use HSA/FSA funds — check your plan. No contracts; cancel before your next renewal. If you stop, your clinician advises on maintenance and what to expect.
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